BenevolentAI Unveils Groundbreaking Drug Discovery Platform Targeting Ulcerative Colitis
BenevolentAI’s Drug Discovery Platform Identifies Novel Target for Ulcerative Colitis
London-based AI innovator BenevolentAI has successfully identified a new biological target for treating ulcerative colitis using its advanced drug discovery platform. This significant discovery was achieved through the use of the company’s target identification tools and machine learning models, which allowed scientists to identify and experimentally validate the candidate without any prior references in published literature or patents linking the specific gene to the disease.
Anne Phelan, Chief Scientific Officer at BenevolentAI, stated, “Ulcerative colitis is a chronic disease that affects 0.2% of the US population and impacts 1.6 million patients across major markets. Unfortunately, it is inadequately managed with current treatment options. Our innovative preclinical candidate aims to fulfill the pressing need for a safe and effective oral therapy. It has shown an improved safety and tolerability profile in comparison to existing IBD treatments. We’re utilizing patient-derived molecular descriptors to accurately target patient subgroups, enhancing trial designs and their potential for success.”
After the identification phase, BenevolentAI harnessed its molecular design capabilities to create a potential oral drug that is peripherally restricted. This candidate has been experimentally validated using ex-vivo colon samples from ulcerative colitis patients who did not respond to existing therapies. Joanna Shields, Chief Executive Officer of BenevolentAI, remarked, “The nomination of a drug candidate linked to a novel target for ulcerative colitis identified through our AI-driven drug discovery platform marks a pivotal moment for BenevolentAI and offers a promising new treatment option for this challenging condition.” BenevolentAI plans to advance this asset into clinical trials in early 2023.
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